Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumor DNA sequencing

BACKGROUND: Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. METHODS: We developed a customizable hybrid-capture cfDNA-Seq technology using...

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出版年:Clin Chem
主要な著者: Mansukhani, Sonia, Barber, Louise J., Kleftogiannis, Dimitrios, Moorcraft, Sing Yu, Davidson, Michael, Woolston, Andrew, Proszek, Paula Zuzanna, Griffiths, Beatrice, Fenwick, Kerry, Herman, Bram, Matthews, Nik, O’Leary, Ben, Hulkki, Sanna, Gonzalez De Castro, David, Patel, Anisha, Wotherspoon, Andrew, Okachi, Aleruchi, Rana, Isma, Begum, Ruwaida, Davies, Matthew N., Powles, Thomas, von Loga, Katharina, Hubank, Michael, Turner, Nick, Watkins, David, Chau, Ian, Cunningham, David, Lise, Stefano, Starling, Naureen, Gerlinger, Marco
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214522/
https://ncbi.nlm.nih.gov/pubmed/30150316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2018.289629
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