Genomic and Transcriptomic Determinants of Therapy Resistance and Immune Landscape Evolution during Anti-EGFR Treatment in Colorectal Cancer

Despite biomarker stratification, the anti-EGFR antibody cetuximab is only effective against a subgroup of colorectal cancers (CRCs). This genomic and transcriptomic analysis of the cetuximab resistance landscape in 35 RAS wild-type CRCs identified associations of NF1 and non-canonical RAS/RAF aberr...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Cell
Egile Nagusiak: Woolston, Andrew, Khan, Khurum, Spain, Georgia, Barber, Louise J., Griffiths, Beatrice, Gonzalez-Exposito, Reyes, Hornsteiner, Lisa, Punta, Marco, Patil, Yatish, Newey, Alice, Mansukhani, Sonia, Davies, Matthew N., Furness, Andrew, Sclafani, Francesco, Peckitt, Clare, Jiménez, Mirta, Kouvelakis, Kyriakos, Ranftl, Romana, Begum, Ruwaida, Rana, Isma, Thomas, Janet, Bryant, Annette, Quezada, Sergio, Wotherspoon, Andrew, Khan, Nasir, Fotiadis, Nikolaos, Marafioti, Teresa, Powles, Thomas, Lise, Stefano, Calvo, Fernando, Guettler, Sebastian, von Loga, Katharina, Rao, Sheela, Watkins, David, Starling, Naureen, Chau, Ian, Sadanandam, Anguraj, Cunningham, David, Gerlinger, Marco
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Cell Press 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6617392/
https://ncbi.nlm.nih.gov/pubmed/31287991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2019.05.013
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