Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumor DNA sequencing

BACKGROUND: Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. METHODS: We developed a customizable hybrid-capture cfDNA-Seq technology using...

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Bibliografiske detaljer
Udgivet i:Clin Chem
Main Authors: Mansukhani, Sonia, Barber, Louise J., Kleftogiannis, Dimitrios, Moorcraft, Sing Yu, Davidson, Michael, Woolston, Andrew, Proszek, Paula Zuzanna, Griffiths, Beatrice, Fenwick, Kerry, Herman, Bram, Matthews, Nik, O’Leary, Ben, Hulkki, Sanna, Gonzalez De Castro, David, Patel, Anisha, Wotherspoon, Andrew, Okachi, Aleruchi, Rana, Isma, Begum, Ruwaida, Davies, Matthew N., Powles, Thomas, von Loga, Katharina, Hubank, Michael, Turner, Nick, Watkins, David, Chau, Ian, Cunningham, David, Lise, Stefano, Starling, Naureen, Gerlinger, Marco
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214522/
https://ncbi.nlm.nih.gov/pubmed/30150316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2018.289629
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