Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumor DNA sequencing

BACKGROUND: Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. METHODS: We developed a customizable hybrid-capture cfDNA-Seq technology using...

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Pubblicato in:Clin Chem
Autori principali: Mansukhani, Sonia, Barber, Louise J., Kleftogiannis, Dimitrios, Moorcraft, Sing Yu, Davidson, Michael, Woolston, Andrew, Proszek, Paula Zuzanna, Griffiths, Beatrice, Fenwick, Kerry, Herman, Bram, Matthews, Nik, O’Leary, Ben, Hulkki, Sanna, Gonzalez De Castro, David, Patel, Anisha, Wotherspoon, Andrew, Okachi, Aleruchi, Rana, Isma, Begum, Ruwaida, Davies, Matthew N., Powles, Thomas, von Loga, Katharina, Hubank, Michael, Turner, Nick, Watkins, David, Chau, Ian, Cunningham, David, Lise, Stefano, Starling, Naureen, Gerlinger, Marco
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214522/
https://ncbi.nlm.nih.gov/pubmed/30150316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2018.289629
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