Ultra-sensitive mutation detection and genome-wide DNA copy number reconstruction by error corrected circulating tumor DNA sequencing

BACKGROUND: Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. METHODS: We developed a customizable hybrid-capture cfDNA-Seq technology using...

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محفوظ في:
التفاصيل البيبلوغرافية
الحاوية / القاعدة:Clin Chem
المؤلفون الرئيسيون: Mansukhani, Sonia, Barber, Louise J., Kleftogiannis, Dimitrios, Moorcraft, Sing Yu, Davidson, Michael, Woolston, Andrew, Proszek, Paula Zuzanna, Griffiths, Beatrice, Fenwick, Kerry, Herman, Bram, Matthews, Nik, O’Leary, Ben, Hulkki, Sanna, Gonzalez De Castro, David, Patel, Anisha, Wotherspoon, Andrew, Okachi, Aleruchi, Rana, Isma, Begum, Ruwaida, Davies, Matthew N., Powles, Thomas, von Loga, Katharina, Hubank, Michael, Turner, Nick, Watkins, David, Chau, Ian, Cunningham, David, Lise, Stefano, Starling, Naureen, Gerlinger, Marco
التنسيق: Artigo
اللغة:Inglês
منشور في: 2018
الموضوعات:
Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC6214522/
https://ncbi.nlm.nih.gov/pubmed/30150316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1373/clinchem.2018.289629
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