Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma

Amplification of the MYCN oncogene predicts treatment resistance in childhood neuroblastoma. We used a MYC target gene signature that predicts poor neuroblastoma prognosis to identify the histone chaperone, FAcilitates Chromatin Transcription (FACT), as a crucial mediator of the MYC signal and a the...

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Bibliografske podrobnosti
izdano v:Sci Transl Med
Main Authors: Carter, Daniel R., Murray, Jayne, Cheung, Belamy B., Gamble, Laura, Koach, Jessica, Tsang, Joanna, Sutton, Selina, Kalla, Heyam, Syed, Sarah, Gifford, Andrew J., Issaeva, Natalia, Biktasova, Asel, Atmadibrata, Bernard, Sun, Yuting, Sokolowski, Nicolas, Ling, Dora, Kim, Patrick Y., Webber, Hannah, Clark, Ashleigh, Ruhle, Michelle, Liu, Bing, Oberthuer, André, Fischer, Matthias, Byrne, Jennifer, Saletta, Federica, Thwe, Le Myo, Purmal, Andrei, Haderski, Gary, Burkhart, Catherine, Speleman, Frank, De Preter, Katleen, Beckers, Anneleen, Ziegler, David S., Liu, Tao, Gurova, Katerina V., Gudkov, Andrei V., Norris, Murray D., Haber, Michelle, Marshall, Glenn M.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6207083/
https://ncbi.nlm.nih.gov/pubmed/26537256
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aab1803
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