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DREAM target reactivation by core transcriptional regulators supports neuroblastoma growth

Chromosome 17q gains are a common alteration in high-risk neuroblastomas with unknown functional significance. We identified a 17q super-enhancer regulated T-box Transcription Factor 2 (TBX2) as constituent of a core regulatory circuitry driving proliferation through enhancing V-myc myelocytomatosis...

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Detalhes bibliográficos
Publicado no:Mol Cell Oncol
Main Authors: Decaesteker, Bieke, De Preter, Katleen, Speleman, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6512935/
https://ncbi.nlm.nih.gov/pubmed/31131299
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1565470
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