In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene regulatory programs could mark tumors with high pluripotency capaci...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Vanhauwaert, Suzanne, Decaesteker, Bieke, De Brouwer, Sara, Leonelli, Carina, Durinck, Kaat, Mestdagh, Pieter, Vandesompele, Jo, Sermon, Karen, Denecker, Geertrui, Van Neste, Christophe, Speleman, Frank, De Preter, Katleen
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269481/
https://ncbi.nlm.nih.gov/pubmed/30504901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35868-5
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