In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene regulatory programs could mark tumors with high pluripotency capaci...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Sci Rep
मुख्य लेखकों: Vanhauwaert, Suzanne, Decaesteker, Bieke, De Brouwer, Sara, Leonelli, Carina, Durinck, Kaat, Mestdagh, Pieter, Vandesompele, Jo, Sermon, Karen, Denecker, Geertrui, Van Neste, Christophe, Speleman, Frank, De Preter, Katleen
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Nature Publishing Group UK 2018
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269481/
https://ncbi.nlm.nih.gov/pubmed/30504901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35868-5
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