TBX2 is a neuroblastoma core regulatory circuitry component enhancing MYCN/FOXM1 reactivation of DREAM targets

Chromosome 17q gains are almost invariably present in high-risk neuroblastoma cases. Here, we perform an integrative epigenomics search for dosage-sensitive transcription factors on 17q marked by H3K27ac defined super-enhancers and identify TBX2 as top candidate gene. We show that TBX2 is a constitu...

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Publicat a:Nat Commun
Autors principals: Decaesteker, Bieke, Denecker, Geertrui, Van Neste, Christophe, Dolman, Emmy M., Van Loocke, Wouter, Gartlgruber, Moritz, Nunes, Carolina, De Vloed, Fanny, Depuydt, Pauline, Verboom, Karen, Rombaut, Dries, Loontiens, Siebe, De Wyn, Jolien, Kholosy, Waleed M., Koopmans, Bianca, Essing, Anke H. W., Herrmann, Carl, Dreidax, Daniel, Durinck, Kaat, Deforce, Dieter, Van Nieuwerburgh, Filip, Henssen, Anton, Versteeg, Rogier, Boeva, Valentina, Schleiermacher, Gudrun, van Nes, Johan, Mestdagh, Pieter, Vanhauwaert, Suzanne, Schulte, Johannes H., Westermann, Frank, Molenaar, Jan J., De Preter, Katleen, Speleman, Frank
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6242972/
https://ncbi.nlm.nih.gov/pubmed/30451831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-06699-9
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