In silico discovery of a FOXM1 driven embryonal signaling pathway in therapy resistant neuroblastoma tumors

Chemotherapy resistance is responsible for high mortality rates in neuroblastoma. MYCN, an oncogenic driver in neuroblastoma, controls pluripotency genes including LIN28B. We hypothesized that enhanced embryonic stem cell (ESC) gene regulatory programs could mark tumors with high pluripotency capaci...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Vanhauwaert, Suzanne, Decaesteker, Bieke, De Brouwer, Sara, Leonelli, Carina, Durinck, Kaat, Mestdagh, Pieter, Vandesompele, Jo, Sermon, Karen, Denecker, Geertrui, Van Neste, Christophe, Speleman, Frank, De Preter, Katleen
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2018
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6269481/
https://ncbi.nlm.nih.gov/pubmed/30504901
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-35868-5
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