Glutathione biosynthesis is upregulated at the initiation of MYCN‐driven neuroblastoma tumorigenesis

The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patients and has been identified as a key driver of tumorigenesis. However, the mechanism by which MYCN promotes tumor initiation is poorly understood. Here we conducted metabolic profiling of pre‐malignan...

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Detalhes bibliográficos
Publicado no:Mol Oncol
Main Authors: Carter, Daniel R., Sutton, Selina K., Pajic, Marina, Murray, Jayne, Sekyere, Eric O., Fletcher, Jamie, Beckers, Anneleen, De Preter, Katleen, Speleman, Frank, George, Rani E., Haber, Michelle, Norris, Murray D., Cheung, Belamy B., Marshall, Glenn M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423163/
https://ncbi.nlm.nih.gov/pubmed/26996379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.02.004
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