An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here our analyses identify ALYREF, expressed from the most common genetic copy number variation in neuroblastoma, chromoso...

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Publicado no:Nat Commun
Main Authors: Nagy, Zsuzsanna, Seneviratne, Janith A., Kanikevich, Maxwell, Chang, William, Mayoh, Chelsea, Venkat, Pooja, Du, Yanhua, Jiang, Cizhong, Salib, Alice, Koach, Jessica, Carter, Daniel R., Mittra, Rituparna, Liu, Tao, Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994381/
https://ncbi.nlm.nih.gov/pubmed/33767157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22143-x
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