MYCN-targeting miRNAs are predominantly downregulated during MYCN-driven neuroblastoma tumor formation

MYCN is a transcription factor that plays key roles in both normal development and cancer. In neuroblastoma, MYCN acts as a major oncogenic driver through pleiotropic effects regulated by multiple protein encoding genes as well as microRNAs (miRNAs). MYCN activity is tightly controlled at the level...

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Sparad:
Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Beckers, Anneleen, Van Peer, Gert, Carter, Daniel R., Mets, Evelien, Althoff, Kristina, Cheung, Belamy B., Schulte, Johannes H., Mestdagh, Pieter, Vandesompele, Jo, Marshall, Glenn M., De Preter, Katleen, Speleman, Frank
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2014
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467143/
https://ncbi.nlm.nih.gov/pubmed/25294817
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