An ALYREF-MYCN coactivator complex drives neuroblastoma tumorigenesis through effects on USP3 and MYCN stability

To achieve the very high oncoprotein levels required to drive the malignant state cancer cells utilise the ubiquitin proteasome system to upregulate transcription factor levels. Here our analyses identify ALYREF, expressed from the most common genetic copy number variation in neuroblastoma, chromoso...

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Xehetasun bibliografikoak
Argitaratua izan da:Nat Commun
Egile Nagusiak: Nagy, Zsuzsanna, Seneviratne, Janith A., Kanikevich, Maxwell, Chang, William, Mayoh, Chelsea, Venkat, Pooja, Du, Yanhua, Jiang, Cizhong, Salib, Alice, Koach, Jessica, Carter, Daniel R., Mittra, Rituparna, Liu, Tao, Parker, Michael W., Cheung, Belamy B., Marshall, Glenn M.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2021
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7994381/
https://ncbi.nlm.nih.gov/pubmed/33767157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-22143-x
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