Glutathione biosynthesis is upregulated at the initiation of MYCN‐driven neuroblastoma tumorigenesis

The MYCN gene is amplified and overexpressed in a large proportion of high stage neuroblastoma patients and has been identified as a key driver of tumorigenesis. However, the mechanism by which MYCN promotes tumor initiation is poorly understood. Here we conducted metabolic profiling of pre‐malignan...

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Publicat a:Mol Oncol
Autors principals: Carter, Daniel R., Sutton, Selina K., Pajic, Marina, Murray, Jayne, Sekyere, Eric O., Fletcher, Jamie, Beckers, Anneleen, De Preter, Katleen, Speleman, Frank, George, Rani E., Haber, Michelle, Norris, Murray D., Cheung, Belamy B., Marshall, Glenn M.
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2016
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5423163/
https://ncbi.nlm.nih.gov/pubmed/26996379
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2016.02.004
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