Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice

Pathological cardiac hypertrophy is associated with the accumulation of lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein in the heart. These aldehydes are metabolized via several pathways, of which aldose reductase (AR) represents a broad-specificity route fo...

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Detalhes bibliográficos
Publicado no:J Mol Cell Cardiol
Main Authors: Baba, Shahid P., Zhang, Deqing, Singh, Mahavir, Dassanayaka, Sujith, Xie, Zhengzhi, Jagatheesan, Ganapathy, Zhao, Jingjing, Schmidtke, Virginia K, Brittian, Kenneth R., Merchant, Michael L., Conklin, Daniel J., Jones, Steven P., Bhatnagar, Aruni
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205513/
https://ncbi.nlm.nih.gov/pubmed/29627295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.04.002
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