Deficiency of aldose reductase exacerbates early pressure overload-induced cardiac dysfunction and autophagy in mice

Pathological cardiac hypertrophy is associated with the accumulation of lipid peroxidation-derived aldehydes such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein in the heart. These aldehydes are metabolized via several pathways, of which aldose reductase (AR) represents a broad-specificity route fo...

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Foilsithe in:J Mol Cell Cardiol
Main Authors: Baba, Shahid P., Zhang, Deqing, Singh, Mahavir, Dassanayaka, Sujith, Xie, Zhengzhi, Jagatheesan, Ganapathy, Zhao, Jingjing, Schmidtke, Virginia K, Brittian, Kenneth R., Merchant, Michael L., Conklin, Daniel J., Jones, Steven P., Bhatnagar, Aruni
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2018
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6205513/
https://ncbi.nlm.nih.gov/pubmed/29627295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2018.04.002
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