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Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability
R loops are nucleic acid structures comprising an DNA–RNA hybrid and a displaced single-stranded DNA. These structures may occur transiently during transcription, playing essential biological functions. However, persistent R loops may become pathological as they are important drivers of genome insta...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6205488/ https://ncbi.nlm.nih.gov/pubmed/30301808 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807258115 |
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