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Harmful R-loops are prevented via different cell cycle-specific mechanisms
Identifying how R-loops are generated is crucial to know how transcription compromises genome integrity. We show by genome-wide analysis of conditional yeast mutants that the THO transcription complex, prevents R-loop formation in G1 and S-phase, whereas the Sen1 DNA-RNA helicase prevents them only...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2021
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8298424/ https://ncbi.nlm.nih.gov/pubmed/34294712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-24737-x |
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