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Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability
During transcription, the mRNA may hybridize with DNA, forming an R loop, which can be physiological or pathological, constituting in this case a source of genomic instability. To understand the mechanism by which eukaryotic cells prevent harmful R loops, we used human activation-induced cytidine de...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5642707/ https://ncbi.nlm.nih.gov/pubmed/28973905 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707845114 |
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