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Human THO–Sin3A interaction reveals new mechanisms to prevent R‐loops that cause genome instability
R‐loops, formed by co‐transcriptional DNA–RNA hybrids and a displaced DNA single strand (ssDNA), fulfill certain positive regulatory roles but are also a source of genomic instability. One key cellular mechanism to prevent R‐loop accumulation centers on the conserved THO/TREX complex, an RNA‐binding...
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| Publicado no: | EMBO J |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5709763/ https://ncbi.nlm.nih.gov/pubmed/29074626 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201797208 |
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