Caricamento...

TDP-43 mutations link Amyotrophic Lateral Sclerosis with R-loop homeostasis and R loop-mediated DNA damage

TDP-43 is a DNA and RNA binding protein involved in RNA processing and with structural resemblance to heterogeneous ribonucleoproteins (hnRNPs), whose depletion sensitizes neurons to double strand DNA breaks (DSBs). Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder, in which 97% of...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:PLoS Genet
Autori principali: Giannini, Marta, Bayona-Feliu, Aleix, Sproviero, Daisy, Barroso, Sonia I., Cereda, Cristina, Aguilera, Andrés
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
Soggetti:
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7755276/
https://ncbi.nlm.nih.gov/pubmed/33301444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009260
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !