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TDP43 and RNA instability in amyotrophic lateral sclerosis

The nuclear RNA-binding protein TDP43 is integrally involved in RNA processing. In accord with this central function, TDP43 levels are tightly regulated through a negative feedback loop, in which TDP43 recognizes its own RNA transcript, destabilizes it, and reduces new TDP43 protein production. In t...

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Bibliographische Detailangaben
Veröffentlicht in:Brain Res
Hauptverfasser: Weskamp, Kaitlin, Barmada, Sami J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5997512/
https://ncbi.nlm.nih.gov/pubmed/29395044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2018.01.015
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