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TDP43 and RNA instability in amyotrophic lateral sclerosis
The nuclear RNA-binding protein TDP43 is integrally involved in RNA processing. In accord with this central function, TDP43 levels are tightly regulated through a negative feedback loop, in which TDP43 recognizes its own RNA transcript, destabilizes it, and reduces new TDP43 protein production. In t...
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| Publicat a: | Brain Res |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5997512/ https://ncbi.nlm.nih.gov/pubmed/29395044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2018.01.015 |
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