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TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are progressive neurodegenerative disorders marked in most cases by the nuclear exclusion and cytoplasmic deposition of the RNA binding protein TDP43. We previously demonstrated that ALS–associated mutant TDP43 accumulates within...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Archbold, Hilary C., Jackson, Kasey L., Arora, Ayush, Weskamp, Kaitlin, Tank, Elizabeth M.-H., Li, Xingli, Miguez, Roberto, Dayton, Robert D., Tamir, Sharon, Klein, Ronald L., Barmada, Sami J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5854632/
https://ncbi.nlm.nih.gov/pubmed/29545601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22858-w
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