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Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
THO/TREX is a conserved complex with a role in messenger ribonucleoprotein biogenesis that links gene expression and genome instability. Here, we show that human THO interacts with MFAP1 (microfibrillar-associated protein 1), a spliceosome-associated factor. Interestingly, MFAP1 depletion impairs ce...
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| Veröffentlicht in: | Cell Rep |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Cell Press
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6693559/ https://ncbi.nlm.nih.gov/pubmed/31390568 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.010 |
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