Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

DSTA4637A, a THIOMAB™ antibody-antibiotic conjugate targeting Staphylococcus aureus, has shown promising bactericidal activity in a mouse model. DSTA4637A consists of a monoclonal anti-S. aureus antibody with an average of two rifalogue antibiotic molecules, dmDNA31, linked to its light chains. The...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:MAbs
Hlavní autoři: Wang-Lin, Shun xin, Zhou, Chenguang, Kamath, Amrita V., Hong, Kyu, Koppada, Neelima, Saad, Ola M., Carrasco-Triguero, Montserrat, Khojasteh, Cyrus, Deng, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis 2018
Témata:
Report
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204815/
https://ncbi.nlm.nih.gov/pubmed/30081725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494478
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky