Minimal physiologically-based pharmacokinetic modeling of DSTA4637A, A novel THIOMAB™ antibody antibiotic conjugate against Staphylococcus aureus, in a mouse model

DSTA4637A, a THIOMAB™ antibody-antibiotic conjugate targeting Staphylococcus aureus, has shown promising bactericidal activity in a mouse model. DSTA4637A consists of a monoclonal anti-S. aureus antibody with an average of two rifalogue antibiotic molecules, dmDNA31, linked to its light chains. The...

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Bibliographische Detailangaben
Veröffentlicht in:MAbs
Hauptverfasser: Wang-Lin, Shun xin, Zhou, Chenguang, Kamath, Amrita V., Hong, Kyu, Koppada, Neelima, Saad, Ola M., Carrasco-Triguero, Montserrat, Khojasteh, Cyrus, Deng, Rong
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2018
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204815/
https://ncbi.nlm.nih.gov/pubmed/30081725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2018.1494478
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