Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicological platforms used during drug development are no...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Toxicol Sci
Main Authors: Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
Teme:
Systems Toxicology and Cka-Mediated Hepatotoxicity
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204762/
https://ncbi.nlm.nih.gov/pubmed/30060248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy191
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