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Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling

PURPOSE: Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V(2) receptor antagonist tolvaptan is approved in multiple countries for the treatment of ADPKD, however its use is associated with clinically significant drug-induc...

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Detalhes bibliográficos
Publicado no:Pharm Res
Main Authors: Woodhead, J. L., Pellegrini, L., Shoda, L. K. M., Howell, B. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944674/
https://ncbi.nlm.nih.gov/pubmed/31909447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2726-0
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