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Comparison of the Hepatotoxic Potential of Two Treatments for Autosomal-Dominant Polycystic Kidney DiseaseUsing Quantitative Systems Toxicology Modeling

PURPOSE: Autosomal-dominant polycystic kidney disease (ADPKD) is an orphan disease with few current treatment options. The vasopressin V(2) receptor antagonist tolvaptan is approved in multiple countries for the treatment of ADPKD, however its use is associated with clinically significant drug-induc...

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Bibliografski detalji
Izdano u:Pharm Res
Glavni autori: Woodhead, J. L., Pellegrini, L., Shoda, L. K. M., Howell, B. A.
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6944674/
https://ncbi.nlm.nih.gov/pubmed/31909447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2726-0
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