Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling

PURPOSE: Macrolide antibiotics are commonly prescribed treatments for drug-resistant bacterial infections; however, many macrolides have been shown to cause liver enzyme elevations and one macrolide, telithromycin, has been pulled from the market by its provider due to liver toxicity. This work seek...

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Publicado en:Pharm Res
Autores principales: Woodhead, Jeffrey L., Yang, Kyunghee, Oldach, David, MacLauchlin, Chris, Fernandes, Prabhavathi, Watkins, Paul B., Siler, Scott Q., Howell, Brett A.
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2019
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6373306/
https://ncbi.nlm.nih.gov/pubmed/30734107
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-019-2582-y
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