Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity

CKA, a chemokine receptor antagonist intended for treating inflammatory conditions, produced dose-dependent hepatotoxicity in rats but advanced into the clinic where single doses of CKA up to 600 mg appeared safe in humans. Because existing toxicological platforms used during drug development are no...

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Bibliografiset tiedot
Julkaisussa:Toxicol Sci
Päätekijät: Battista, Christina, Yang, Kyunghee, Stahl, Simone H, Mettetal, Jerome T, Watkins, Paul B, Siler, Scott Q, Howell, Brett A
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Oxford University Press 2018
Aiheet:
Systems Toxicology and Cka-Mediated Hepatotoxicity
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204762/
https://ncbi.nlm.nih.gov/pubmed/30060248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfy191
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