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Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

Interferons (IFNs) and inflammasomes are essential mediators of anti-microbial immunity. Type I IFN signaling drives activation of the AIM2 inflammasome in macrophages; however, the relative contribution of IFNs and inflammasome responses in host defense is less understood. We report intact AIM2 inf...

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Bibliografiske detaljer
Udgivet i:Cell Rep
Main Authors: Zhu, Qifan, Man, Si Ming, Karki, Rajendra, Malireddi, R.K. Subbarao, Kanneganti, Thirumala-Devi
Format: Artigo
Sprog:Inglês
Udgivet: 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6204211/
https://ncbi.nlm.nih.gov/pubmed/29562174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.02.096
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