Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

Lysosomal cathepsins regulate an exquisite range of biological functions, and their deregulation is associated with inflammatory, metabolic, and degenerative diseases in humans. In this study, we identified a key cell-intrinsic role for cathepsin B as a negative feedback regulator of lysosomal bioge...

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Udgivet i:J Exp Med
Main Authors: Qi, Xiaopeng, Man, Si Ming, Malireddi, R.K. Subbarao, Karki, Rajendra, Lupfer, Christopher, Gurung, Prajwal, Neale, Geoffrey, Guy, Clifford S., Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2016
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5030800/
https://ncbi.nlm.nih.gov/pubmed/27551156
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20151938
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