The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection

Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms controlling activation of the AIM2 inflammasome in response to different cytosolic pathogens is unclear. Here, we show that the transcription factor IRF1 is the upstream molecule leading to AIM2 inflamma...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Man, Si Ming, Karki, Rajendra, Malireddi, R.K. Subbarao, Neale, Geoffrey, Vogel, Peter, Yamamoto, Masahiro, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406811/
https://ncbi.nlm.nih.gov/pubmed/25774715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3118
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