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The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection
Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms controlling activation of the AIM2 inflammasome in response to different cytosolic pathogens is unclear. Here, we show that the transcription factor IRF1 is the upstream molecule leading to AIM2 inflamma...
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| 出版年: | Nat Immunol |
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| 主要な著者: | , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4406811/ https://ncbi.nlm.nih.gov/pubmed/25774715 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3118 |
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