The transcription factor IRF1 and guanylate-binding proteins target AIM2 inflammasome activation by Francisella infection

Inflammasomes are critical for mounting host defense against pathogens. The molecular mechanisms controlling activation of the AIM2 inflammasome in response to different cytosolic pathogens is unclear. Here, we show that the transcription factor IRF1 is the upstream molecule leading to AIM2 inflamma...

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發表在:Nat Immunol
Main Authors: Man, Si Ming, Karki, Rajendra, Malireddi, R.K. Subbarao, Neale, Geoffrey, Vogel, Peter, Yamamoto, Masahiro, Lamkanfi, Mohamed, Kanneganti, Thirumala-Devi
格式: Artigo
語言:Inglês
出版: 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4406811/
https://ncbi.nlm.nih.gov/pubmed/25774715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.3118
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