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Gasdermin D promotes AIM2 inflammasome activation and is required for host protection against Francisella novicida
The DNA sensor absent in melanoma 2 (AIM2) forms inflammasome complex with ASC and caspase-1 in response to Francisella tularensis subsp. novicida (F. novicida) infection leading to maturation of IL-1β and IL-18 and pyroptosis. AIM2 is critical for host protection against F. novicida infection in vi...
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| 出版年: | J Immunol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6317867/ https://ncbi.nlm.nih.gov/pubmed/30404813 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800788 |
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