Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due...

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Détails bibliographiques
Publié dans:Antimicrob Agents Chemother
Auteurs principaux: Keniya, Mikhail V., Sabherwal, Manya, Wilson, Rajni K., Woods, Matthew A., Sagatova, Alia A., Tyndall, Joel D. A., Monk, Brian C.
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2018
Sujets:
Mechanisms of Action: Physiological Effects
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201081/
https://ncbi.nlm.nih.gov/pubmed/30126961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01134-18
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