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Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase

Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined how commonly occurring single site mutations in pa...

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Vydáno v:Sci Rep
Hlavní autoři: Sagatova, Alia A., Keniya, Mikhail V., Wilson, Rajni K., Sabherwal, Manya, Tyndall, Joel D. A., Monk, Brian C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4870556/
https://ncbi.nlm.nih.gov/pubmed/27188873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26213
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