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Triazole resistance mediated by mutations of a conserved active site tyrosine in fungal lanosterol 14α-demethylase
Emergence of fungal strains showing resistance to triazole drugs can make treatment of fungal disease problematic. Triazole resistance can arise due to single mutations in the drug target lanosterol 14α-demethylase (Erg11p/CYP51). We have determined how commonly occurring single site mutations in pa...
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| Publicado no: | Sci Rep |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4870556/ https://ncbi.nlm.nih.gov/pubmed/27188873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep26213 |
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