Impact of Homologous Resistance Mutations from Pathogenic Yeast on Saccharomyces cerevisiae Lanosterol 14α-Demethylase

Fungal infections frequently affect immunodeficient individuals and are estimated to kill 1.35 million people per annum. Azole antifungals target the membrane-bound cytochrome P450 monooxygenase lanosterol 14α-demethylase (CYP51; Erg11p). Mutations in CYP51 can render the widely used triazole drugs...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Sagatova, Alia A., Keniya, Mikhail V., Tyndall, Joel D. A., Monk, Brian C.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2018
Témata:
Mechanisms of Resistance
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5826108/
https://ncbi.nlm.nih.gov/pubmed/29263059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02242-17
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