Structural and Functional Elucidation of Yeast Lanosterol 14α-Demethylase in Complex with Agrochemical Antifungals

Azole antifungals, known as demethylase inhibitors (DMIs), target sterol 14α-demethylase (CYP51) in the ergosterol biosynthetic pathway of fungal pathogens of both plants and humans. DMIs remain the treatment of choice in crop protection against a wide range of fungal phytopathogens that have the po...

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Publicado en:PLoS One
Autores principales: Tyndall, Joel D. A., Sabherwal, Manya, Sagatova, Alia A., Keniya, Mikhail V., Negroni, Jacopo, Wilson, Rajni K., Woods, Matthew A., Tietjen, Klaus, Monk, Brian C.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2016
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5132298/
https://ncbi.nlm.nih.gov/pubmed/27907120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167485
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