Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due...

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Pubblicato in:Antimicrob Agents Chemother
Autori principali: Keniya, Mikhail V., Sabherwal, Manya, Wilson, Rajni K., Woods, Matthew A., Sagatova, Alia A., Tyndall, Joel D. A., Monk, Brian C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2018
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Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201081/
https://ncbi.nlm.nih.gov/pubmed/30126961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01134-18
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