Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Keniya, Mikhail V., Sabherwal, Manya, Wilson, Rajni K., Woods, Matthew A., Sagatova, Alia A., Tyndall, Joel D. A., Monk, Brian C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2018
Matèries:
Mechanisms of Action: Physiological Effects
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201081/
https://ncbi.nlm.nih.gov/pubmed/30126961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01134-18
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