Crystal Structures of Full-Length Lanosterol 14α-Demethylases of Prominent Fungal Pathogens Candida albicans and Candida glabrata Provide Tools for Antifungal Discovery

Targeting lanosterol 14α-demethylase (LDM) with azole drugs provides prophylaxis and treatments for superficial and disseminated fungal infections, but cure rates are not optimal for immunocompromised patients and individuals with comorbidities. The efficacy of azole drugs has also been reduced due...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Antimicrob Agents Chemother
Egile Nagusiak: Keniya, Mikhail V., Sabherwal, Manya, Wilson, Rajni K., Woods, Matthew A., Sagatova, Alia A., Tyndall, Joel D. A., Monk, Brian C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2018
Gaiak:
Mechanisms of Action: Physiological Effects
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201081/
https://ncbi.nlm.nih.gov/pubmed/30126961
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01134-18
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak