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The epithelial Na(+) channel γ subunit autoinhibitory tract suppresses channel activity by binding the γ subunit's finger–thumb domain interface

Epithelial Na(+) channel (ENaC) maturation and activation require proteolysis of both the α and γ subunits. Cleavage at multiple sites in the finger domain of each subunit liberates their autoinhibitory tracts. Synthetic peptides derived from the proteolytically released fragments inhibit the channe...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Balchak, Deidra M., Thompson, Rebecca N., Kashlan, Ossama B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6200929/
https://ncbi.nlm.nih.gov/pubmed/30131333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004362
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