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The epithelial Na(+) channel γ subunit autoinhibitory tract suppresses channel activity by binding the γ subunit's finger–thumb domain interface
Epithelial Na(+) channel (ENaC) maturation and activation require proteolysis of both the α and γ subunits. Cleavage at multiple sites in the finger domain of each subunit liberates their autoinhibitory tracts. Synthetic peptides derived from the proteolytically released fragments inhibit the channe...
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| Publicado en: | J Biol Chem |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6200929/ https://ncbi.nlm.nih.gov/pubmed/30131333 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.004362 |
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