Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively...

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Gepubliceerd in:J Autoimmun
Hoofdauteurs: Sanchez-Blanco, Cristina, Clarke, Fiona, Cornish, Georgina H., Depoil, David, Thompson, Stephen J., Dai, Xuezhi, Rawlings, David J., Dustin, Michael L., Zamoyska, Rose, Cope, Andrew P., Purvis, Harriet A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Academic Press 2018
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6198113/
https://ncbi.nlm.nih.gov/pubmed/30054208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jaut.2018.07.008
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