Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno‐receptors. Fungal β‐glucan receptor dectin‐1 signals via Syk, and dectin‐1 stimula...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Purvis, Harriet A, Clarke, Fiona, Jordan, Christine K, Blanco, Cristina Sanchez, Cornish, Georgina H, Dai, Xuezhi, Rawlings, David J, Zamoyska, Rose, Cope, Andrew P
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Immunodeficiencies and autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859948/
https://ncbi.nlm.nih.gov/pubmed/28948613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747092
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