Loss of the Protein Tyrosine Phosphatase PTPN22 Reduces Mannan-Induced Autoimmune Arthritis in SKG Mice

The cytoplasmic phosphatase, protein tyrosine phosphatase nonreceptor type 22 (PTPN22), is a negative regulator of T cell signaling. Genome-wide association studies have shown that single-nucleotide polymorphisms in PTPN22 confer an increased risk of developing multiple autoimmune diseases in humans...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Sood, Shatakshi, Brownlie, Rebecca J., Garcia, Celine, Cowan, Graeme, Salmond, Robert J., Sakaguchi, Shimon, Zamoyska, Rose
Formato: Artigo
Idioma:Inglês
Publicado em: AAI 2016
Assuntos:
Autoimmunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4932175/
https://ncbi.nlm.nih.gov/pubmed/27288531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1502656
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