Protein tyrosine phosphatase PTPN22 regulates IL‐1β dependent Th17 responses by modulating dectin‐1 signaling in mice

A single nucleotide polymorphism within the PTPN22 gene is a strong genetic risk factor predisposing to the development of multiple autoimmune diseases. PTPN22 regulates Syk and Src family kinases downstream of immuno‐receptors. Fungal β‐glucan receptor dectin‐1 signals via Syk, and dectin‐1 stimula...

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Dades bibliogràfiques
Publicat a:Eur J Immunol
Autors principals: Purvis, Harriet A, Clarke, Fiona, Jordan, Christine K, Blanco, Cristina Sanchez, Cornish, Georgina H, Dai, Xuezhi, Rawlings, David J, Zamoyska, Rose, Cope, Andrew P
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Immunodeficiencies and autoimmunity
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859948/
https://ncbi.nlm.nih.gov/pubmed/28948613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201747092
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