Protein tyrosine phosphatase PTPN22 is dispensable for dendritic cell antigen processing and promotion of T-cell activation by dendritic cells

The PTPN22(R620W) single nucleotide polymorphism increases the risk of developing multiple autoimmune diseases including type 1 diabetes, rheumatoid arthritis and lupus. PTPN22 is highly expressed in antigen presenting cells (APCs) where the expression of the murine disease associated variant orthol...

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Vydáno v:PLoS One
Hlavní autoři: Clarke, Fiona, Jordan, Christine K., Gutiérrez-Martinez, Enrique, Bibby, Jack A., Sanchez-Blanco, Cristina, Cornish, Georgina H., Dai, Xuezhi, Rawlings, David J., Zamoyska, Rose, Guermonprez, Pierre, Cope, Andrew P., Purvis, Harriet A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5645108/
https://ncbi.nlm.nih.gov/pubmed/29040339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0186625
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