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Bypassing a 8,5′-cyclo-2′-deoxyadenosine lesion by human DNA polymerase η at atomic resolution

Oxidatively induced DNA lesions 8,5′-cyclopurine-2′-deoxynucleosides (cdPus) are prevalent and cytotoxic by impeding DNA replication and transcription. Both the 5′R- and 5′S-diastereomers of cdPu can be removed by nucleotide excision repair; however, the 5′S-cdPu is more resistant to repair than the...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Weng, Peter J., Gao, Yang, Gregory, Mark T., Wang, Pengcheng, Wang, Yinsheng, Yang, Wei
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6196489/
https://ncbi.nlm.nih.gov/pubmed/30275308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1812856115
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