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Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II

Alkylative damage to DNA can be induced by environmental chemicals, endogenous metabolites and some commonly prescribed chemotherapeutic agents. The regioisomeric N3-, O(2)- and O(4)-ethylthymidine (N3-, O(2)- and O(4)-EtdT, respectively) represent an important class of ethylated DNA lesions. Using...

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Bibliografske podrobnosti
izdano v:Nucleic Acids Res
Main Authors: You, Changjun, Wang, Pengcheng, Dai, Xiaoxia, Wang, Yinsheng
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267633/
https://ncbi.nlm.nih.gov/pubmed/25404131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1183
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