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Transcriptional bypass of regioisomeric ethylated thymidine lesions by T7 RNA polymerase and human RNA polymerase II

Alkylative damage to DNA can be induced by environmental chemicals, endogenous metabolites and some commonly prescribed chemotherapeutic agents. The regioisomeric N3-, O(2)- and O(4)-ethylthymidine (N3-, O(2)- and O(4)-EtdT, respectively) represent an important class of ethylated DNA lesions. Using...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: You, Changjun, Wang, Pengcheng, Dai, Xiaoxia, Wang, Yinsheng
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4267633/
https://ncbi.nlm.nih.gov/pubmed/25404131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gku1183
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